The first Japanese Encephalitis vaccine was launched in 2012 by Indian vaccine maker Biological E. The vaccine, branded by the name Jeev, is to be delivered in two doses with a four-week gap.<\/p>\n
Japanese Encephalitis is a viral disease that infects animals and humans. It is transmitted by mosquitoes and causes inflammation of the membranes around the brain. World Health Organisation describes that the infections are mild (fever and headache) or without apparent symptoms, but approximately 1 in 250 infections results in severe clinical illness.<\/p>\n
The incubation period is between 4-14 days. In children, gastrointestinal pain and vomiting may be the dominant initial symptoms. Severe disease is characterized by rapid onset of high fever, headache, neck stiffness, disorientation, coma, seizures, spastic paralysis and ultimately death. The case-fatality rate can be as high as 30% among those with disease symptoms.<\/p>\n
Of those who survive, 20%\u201330% suffer permanent intellectual, behavioural or neurological sequel such as paralysis, recurrent seizures or the inability to speak.<\/p>\n
Network 18\u2019s news agency Moneycontrol.com says that approximately six crore people in North and East India live in JE-endemic regions. Around 1,500 to 4,000 cases are reported every year.<\/p>\n
Biological E tied-up with Austrian biotech company Intercell to develop, manufacture and market the vaccine in South Asia. It also built a 10 million dosage manufacturing facility to meet domestic and export demand.<\/p>\n
WHO prequalified the eligibility criteria for Jeev, thereby allowing its supply in most markets, and in a year\u2019s time, it hit the markets.<\/p>\n
This vaccine was a public-private collaborative effort, jointly developed by scientists at the Indian Council of Medical Research (ICMR), the National Institute of Virology (NIV) and Bharat Biotech International.<\/p>\n
In fact, when the vaccine was launched, government officials claimed that the vaccine would potentially reduce India\u2019s dependence on Chinese imports. Till Jeeva was launched, the Indian government was buying the live attenuated SA14-14-2 vaccine manufactured by state-run Chengdu Institute of Biological Products (CDIBP).<\/p>\n
China\u2019s challenge<\/strong><\/p>\n Even after Jeev hit the markets, the Indian government continued to import JE vaccines from CDIBP through public sector undertaking HLL Lifecare.<\/p>\n \u201cThe Chinese company which built huge capacities has been dumping the vaccine 20-30 cents to a dollar in India per dose, we could not compete at that price,\u201d a top executive from one of the vaccine companies mentioned in the story told Moneycontrol.com, adding, \u201cThe vaccines made by Indian companies are much safer inactivated vaccine based on cell-culture, where a dead strain is used, compared to Chinese which uses live-attenuated or live virus.\u201d<\/p>\n \u201cWith Indian government not buying our vaccines, we had to survive on export orders which are infrequent,\u201d the executive added. \u201cJE is a campaign vaccination and so is not a part of the national immunisation programme. It is covered under public immunisation confined to the 181 endemic districts in the country,\u201d said Pushpa Vijayraghavan, Director of Sathguru Management Consultants.<\/p>\n \u201cThe problem in JE vaccine is that there is lack of substantial market creation because campaign vaccine volume is not very high, the markets are less stable and less attractive. It is possible the Chinese may have substantial economies of scale, cross-subsidising the vaccine, or could it be a case of stockpiling to respond immediately to demand,\u201d Vijayraghavan added.<\/p>\n